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The isolated nucleic acid of claim 1, 2, or 3, wherein the encoded modified tetracycline repressor binds to a tetracycline operator sequence in a prokaryotic organism with a greater affinity in the presence of tetracycline or a tetracycline analog than in the absence of tetracycline or the tetracycline analog with a greater affinity at 28° C! In 2005, the Supreme Court held that Title IX’s private right of action encompasses claims of retaliation against an individual for complaining about sex discrimination because such retaliation is an example of the intentional sex-based discrimination prohibited by Title IX!
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